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              Recombinant Mouse M-CSF巨噬細胞集落刺激因子

              • 更新時間:  2023-07-24
              • 產品型號:  R&D 416-ml
              • 簡單描述
              • Recombinant Mouse M-CSF巨噬細胞集落刺激因子
                上海力敏代理R&D產品,美國*Recombinant Mouse M-CSF,Recombinant human M-CSF,規格分別是10ug和50ug 咨詢
                還有人的Human M-CSF
              詳細介紹

              Recombinant Mouse M-CSF巨噬細胞集落刺激因子

              MCSF,
              also known as CSF1,
              is a fourαhelicalbundle
              cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1 3).
              MCSF
              is also essential for the survival and proliferation of osteoclast progenitors (1, 4). MCSF
              also primes and enhances macrophage killing of tumor cells and
              microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). MCSF
              increases during
              pregnancy to support implantation and growth of the decidua and placenta (5). Sources of MCSF
              include fibroblasts, activated macrophages, endometrial secretory
              epithelium, bone marrow stromal cells and activated endothelial cells (1 5).
              The MCSF
              receptor (cfms)
              transduces its pleotropic effects and mediates its
              endocytosis. MCSF
              mRNAs of various sizes occur (3 9).
              Full length mouse MCSF
              transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with
              a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two
              proteolytically cleaved, secreted dimers. One is an Nand
              Oglycosylated
              86 kDa dimer, while the other is modified by both glycosylation and chondroitinsulfate
              proteoglycan (PG) to generate a 200 kDa subunit. Although PGmodified
              MCSF
              can circulate, it may be immobilized by attachment to type V collagen (8). Shorter
              transcripts encode M CSF
              that lacks cleavage and PG sites and produces an Nglycosylated
              68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7).
              Although forms may vary in activity and halflife,
              all contain the Nterminal
              150 aa portion that is necessary and sufficient for interaction with the M CSF
              receptor
              (10, 11). The first 229 aa of mature mouse MCSF
              shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human MCSF,
              respectively (12, 13). Human MCSF
              is active in the mouse, but mouse MCSF
              is reported to be speciesspecific

              Recombinant Mouse M-CSF巨噬細胞集落刺激因子

               

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